01of 10TJ Osborne and Darius RuckerAustin Friedline"I’ve been in this town for 12 years and I’ve gotten to know a lot of people," Rucker told the crowd. “But some people you get toreallyknow and they become family. These guys are family.”
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TJ Osborne and Darius Rucker
Austin Friedline

“I’ve been in this town for 12 years and I’ve gotten to know a lot of people,” Rucker told the crowd. “But some people you get toreallyknow and they become family. These guys are family.”
02of 10John and TJ OsborneAustin FriedlineThe brothers played their hits “It Ain’t My Fault,” “Shoot Me Straight” and new single “I’m Not for Everyone.”
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John and TJ Osborne

The brothers played their hits “It Ain’t My Fault,” “Shoot Me Straight” and new single “I’m Not for Everyone.”
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Darius Rucker
Keith Griner

Rucker then took the stage solo to tell a story before covering Nanci Griffith’s “I Wish It Would Rain” in tribute to the late singer-songwriter.
“Years later, my mom had a heart attack and went into a coma. I sat in that hospital room for eight hours and I sang this song over and over. This weekNanci died. She’s one of my great friends and I want to play this song because it means so much to me.”
04of 10John Daly and Darius RuckerAustin FriedlineLegendary golfer John Daly was a surprise guest, joining Rucker for a rousing rendition of “Knockin' on Heaven’s Door.”
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John Daly and Darius Rucker

Legendary golfer John Daly was a surprise guest, joining Rucker for a rousing rendition of “Knockin' on Heaven’s Door.”
05of 10Jason AldeanKeith GrinerIntroducing Aldean, Rucker told the crowd, “I would do anything for him, and I know he’d do anything for me.” That country singer agreed, but not before teasing Rucker a bit. “He did me dirty making me follow a Hootie song!” joked Aldean, who took the stage after “Hold My Hand.“Playing stripped-down versions of “Big Green Tractor” and “Any Ol' Barstool,” Aldean added, “Darius really is one of the nicest, coolest guys in town and so it’s a pleasure to be here, especially for St. Jude.”
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Jason Aldean

Introducing Aldean, Rucker told the crowd, “I would do anything for him, and I know he’d do anything for me.” That country singer agreed, but not before teasing Rucker a bit. “He did me dirty making me follow a Hootie song!” joked Aldean, who took the stage after “Hold My Hand.”
Playing stripped-down versions of “Big Green Tractor” and “Any Ol' Barstool,” Aldean added, “Darius really is one of the nicest, coolest guys in town and so it’s a pleasure to be here, especially for St. Jude.”
06of 10Darius Rucker and Keb' Mo’Darius Rucker and Keb' Mo'.Austin FriedlineRucker then introduced Grammy-winner Keb' Mo', who played “Rita” and “I Remember You” before inviting Rucker back to join him on Marvin Gaye classic “What’s Going On.”
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Darius Rucker and Keb' Mo'
Darius Rucker and Keb' Mo'.Austin Friedline

Rucker then introduced Grammy-winner Keb' Mo', who played “Rita” and “I Remember You” before inviting Rucker back to join him on Marvin Gaye classic “What’s Going On.”
07of 10Jennifer Wayne, Naomi Cooke and Natalie Stovall of Runaway JuneKeith GrinerFor the final surprise of the night, Runaway June hit the Ryman stage.
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Jennifer Wayne, Naomi Cooke and Natalie Stovall of Runaway June

For the final surprise of the night, Runaway June hit the Ryman stage.
08of 10Runaway JuneKeith GrinerThe trio played their hit “Buy My Own Drinks” as well as their latest, “T-Shirt” before leading an audience sing-along to the Tom Petty classic “American Girl.”
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Runaway June

The trio played their hit “Buy My Own Drinks” as well as their latest, “T-Shirt” before leading an audience sing-along to the Tom Petty classic “American Girl.”
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Darius Rucker and Tiffany Turner with Lee Turner

10of 10The band close out the nightKeith GrinerIn 12 years of Darius and Friends, the event has raised over $2.5 million forSt. Jude Children’s Research Hospital. “You see these kids who are sick, and they’re so happy to be there, because their caregivers are so loving and giving to them,” Ruckerrecently toldThe Tennessean. “And then you find out that nobody ever gets a bill. That blew me away. I was just like, ‘We’ll figure out some way to help you guys as much as I can.'”
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The band close out the night

In 12 years of Darius and Friends, the event has raised over $2.5 million forSt. Jude Children’s Research Hospital. “You see these kids who are sick, and they’re so happy to be there, because their caregivers are so loving and giving to them,” Ruckerrecently toldThe Tennessean. “And then you find out that nobody ever gets a bill. That blew me away. I was just like, ‘We’ll figure out some way to help you guys as much as I can.'”
source: people.com